Notch3 signaling promotes tumor cell adhesion and progression in a murine epithelial ovarian cancer model.
High grade serous ovarian cancer (HGSC) is the most common and deadly type of ovarian cancer, largely due to difficulties in early diagnosis jerome brown jersey and rapid metastasis throughout the peritoneal cavity.Previous studies have shown that expression of Notch3 correlates with worse prognosis and increased tumorigenic cell behaviors in HGSC.